FIRST DELINEATION OF 5-HT1A RECEPTOR IN HUMAN BRAIN WITH PET AND [C-11]WAY-100635

被引：90

作者：

PIKE, VW

MCCARRON, JA

LAMMERSTMA, AA

HUME, SP

POOLE, K

GRASBY, PM

MALIZIA, A

CLIFFE, IA

FLETCHER, A

BENCH, C

机构：

[1] WYETH RES UK LTD,MAIDENHEAD SL6 0PH,BERKS,ENGLAND

[2] CHARING CROSS & WESTMINSTER MED SCH,LONDON W6 8RF,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 283卷 / 1-3期

关键词：

5-HT1A RECEPTOR; HUMAN; PET (POSITRON EMISSION TOMOGRAPHY); C-11] WAY-100635;

D O I：

10.1016/0014-2999(95)00438-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The selective 5-HT1A receptor radioligand, [C-11]WAY-100635 {[C-11]N-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)N-2-pyridyl)cyclohexanecarboxamide}, has been injected intravenously into healthy male volunteers and studied by PET (positron emission tomography). The results provide the first delineation of 5-HT1A receptors in living human brain and demonstrate the potential to use [C-11]WAY-100635 for the study of central 5-HT1A receptors in patients with psychiatric and neurological disorders and for the investigation of the pharmacology of drugs acting on the central nervous system.

引用

页码：R1 / R3

页数：3

共 6 条

[1] EVALUATION OF [O-METHYL-H-3]WAY-100635 AS AN IN-VIVO RADIOLIGAND FOR 5-HT1A RECEPTORS IN RAT-BRAIN [J].