SYNTHETIC APPLICATIONS OF ARENETRICARBONYLCHROMIUM(0) COMPLEXES - THE SYNTHESIS OF POLYFUNCTIONALISED THIOPHENES

被引：13

作者：

LOFT, MS

MOWLEM, TJ

WIDDOWSON, DA

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] SHELL RES LTD,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 02期

关键词：

D O I：

10.1039/p19950000097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithiation of thiophenetricarbonylchromium(o) complexes with butyllithium occurs preferentially at C-2/5 but when these are blocked, 3/4 lithiation is facile. Combinations of a bulky silyl ((Pr3Si)-Si-i or Bu(t)'Me(2)Si) blocking group at C-2/5 and remote lithiation/electrophilic quench of C-3/4 followed by desilylation/lithiation/electrophilic quench allowed the synthesis of 2,3-. 2,3,5- and 2.3,4,5-polysubstituted thiophene complexes and their derived free thiophenes.

引用

页码：97 / 104

页数：8

共 40 条

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