SYNTHESIS OF NUCLEOSIDES AND RELATED-COMPOUNDS .21. SYNTHESIS OF 9-(T-2,C-3-DIHYDROXYMETHYL-R-1-CYCLOPROPYL)-9H-ADENINE (A LOWER METHYLENE HOMOLOG OF CARBOCYCLIC OXETANOCIN) AND RELATED-COMPOUNDS

被引：37

作者：

KATAGIRI, N

SATO, H

KANEKO, C

机构：

[1] Pharmaceutical Institute, Tohoku University, Aobayama

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 11期

关键词：

adenine; antiviral activity; BLV; carbocyclic oxetanocin; cyclopropane; high pressure; thymine;

D O I：

10.1248/cpb.38.3184

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：3184 / 3186

页数：3

共 13 条

[1]

BIRON KK, 1984, HERPESVIRUS, P677

[2]

CHIBA T, IN PRESS CHEM PHARM

[3] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE [J].