POSSIBLE INVOLVEMENT OF HUMAN-D MINIGENES IN THE 1ST COMPLEMENTARITY-DETERMINING REGION OF KAPPA-LIGHT CHAINS

被引：2

作者：

CHEN, PP

KABAT, EA

WU, TT

FONG, S

CARSON, DA

机构：

[1] SCRIPPS CLIN & RES FDN, DEPT BASIC & CLIN RES, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

[2] COLUMBIA UNIV, DEPT MICROBIOL, NEW YORK, NY 10032 USA

[3] COLUMBIA UNIV, DEPT HUMAN GENET & DEV, NEW YORK, NY 10032 USA

[4] COLUMBIA UNIV, DEPT NEUROL, NEW YORK, NY 10032 USA

[5] COLUMBIA UNIV, CTR CANC, INST CANC RES, NEW YORK, NY 10032 USA

[6] NIAID, BETHESDA, MD 20205 USA

[7] NORTHWESTERN UNIV, DEPT BIOCHEM, EVANSTON, IL 60201 USA

[8] NORTHWESTERN UNIV, DEPT MOLEC BIOL & CELL BIOL, EVANSTON, IL 60201 USA

[9] NORTHWESTERN UNIV, DEPT ENGN SCI & APPL MATH, EVANSTON, IL 60201 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1985年 / 82卷 / 07期

关键词：

D O I：

10.1073/pnas.82.7.2125

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nucleotide sequence of the complementary strands of 2 human diversity region (D) minigenes, D2 and D4, show stretches of homology with 2 human variable region .kappa. chain (V.kappa.) genes, NG9 and HK101, respectively, in the 1st complementarity-determining region. In one V.kappa. sequence, the homology includes the 5'' flanking region of D minigenes, which may comprise a recombinase recognition signal. Gene conversions involving D minigenes may contribute to VK diversity.

引用

页码：2125 / 2127

页数：3

共 47 条

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