DEUTERIUM NMR-SPECTROSCOPY OF BIOFLUIDS FOR THE IDENTIFICATION OF DRUG METABOLITES - APPLICATION TO N,N-DIMETHYLFORMAMIDE

被引：15

作者：

FARRANT, RD

SALMAN, SR

LINDON, JC

CUPID, BC

NICHOLSON, JK

机构：

[1] WELLCOME RES LABS,DEPT PHYS SCI,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] UNIV BAGHDAD,COLL SCI,BAGHDAD,IRAQ

[3] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,LONDON WC1H 0PP,ENGLAND

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 08期

关键词：

H-2-NMR; METABOLISM; URINE; DMF; H-2-C-13; CORRELATION;

D O I：

10.1016/0731-7085(93)80175-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The metabolism of N,N-dimethylformamide in the Sprague-Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of N,N-dimethylformamide-d7 (DMF-d7) and H-2-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional H-2-C-13 correlation with C-13 decoupling aided metabolite identification through the provision of C-13 chemical shifts.

引用

页码：687 / 692

页数：6

共 10 条

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