APPLICATION OF PARTICLE-BEAM MASS-SPECTROMETRY TO DRUGS - AN EXAMINATION OF THE PARAMETERS AFFECTING SENSITIVITY

被引：5

作者：

TILLER, PR

机构：

[1] Structural Chemistry Department, Glaxo Group Research Ltd., Greenford, Middlesex UB6 OHE, Greenford Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 647卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83329-Q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The qualitative performance of a particle-beam interface is evaluated by an examination of the effects of altering the pressure of the nebulisation gas, the nebuliser position, the desolvation chamber temperature, the temperature of the nebulisation gas, the temperature of the source and the solvent composition. All these parameters have an impact on performance excepting the nebulisation gas temperature. A summary of the ''optimum'' settings for routine operation is given.

引用

页码：101 / 105

页数：5

共 5 条

[1] QUANTITATION AND LINEARITY FOR PARTICLE-BEAM LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY
APFFEL, A
PERRY, ML
[J]. JOURNAL OF CHROMATOGRAPHY, 1991, 554 (1-2): : 103 - 118
[2] INVESTIGATION OF ENHANCED ION ABUNDANCES FROM A CARRIER PROCESS IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY PARTICLE BEAM MASS-SPECTROMETRY
BELLAR, TA
BEHYMER, TD
BUDDE, WL
[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1990, 1 (01) : 92 - 98
[3] THE MATRIX EFFECT IN PARTICLE BEAM LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY AND RELIABLE QUANTIFICATION BY ISOTOPE-DILUTION
BROWN, FR
DRAPER, WM
[J]. BIOLOGICAL MASS SPECTROMETRY, 1991, 20 (09) : 515 - 521
[4] TINKE A P, 1991, Journal of Chromatography, V554, P119, DOI 10.1016/S0021-9673(01)88442-9
[5] OPTIMIZATION AND APPLICATION OF PARTICLE BEAM HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY TO COMPOUNDS OF PHARMACEUTICAL INTEREST
VOYKSNER, RD
SMITH, CS
KNOX, PC
[J]. BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1990, 19 (09): : 523 - 534

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