FALSE-POSITIVE TREPONEMAL SEROLOGY IN PATIENTS WITH DIABETES-MELLITUS

被引：10

作者：

BRAUNER, A

CARLSSON, B

SUNDKVIST, G

OSTENSON, CG

机构：

[1] Department of Clinical Bacteriology, Stockholm County Council Central Microbiological Laboratory, Stockholm

[2] Department of Medicine, University of Lund, Malmö General Hospital, Malmö

[3] Department of Endocrinology, Karolinska Hospital, Stockholm

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 1994年 / 8卷 / 01期

关键词：

D O I：

10.1016/1056-8727(94)90013-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In sera from 476 diabetic outpatients, positive reaction in the Fluorescent Treponemal Antibody-Absorption (FTA-Abs) test, a commonly used serological test for syphilis, was found in 36 of the patients. None of 100 healthy control subjects were positive in the FTA-Abs test. Additional treponemal and nontreponemal tests confirmed the diagnosis of syphilis in only three of the diabetic patients. In 10 of the 36 patients, the positive FTA-Abs reactivity appeared to be due to cross-reactivity between the treponemal antigen and Borrelia burgdorferi, which causes Lyme borreliosis. In the remaining 23 patients (5%), no other explanation for a false-positive FTA-Abs reactivity was found besides diabetes. Diabetic patients with false-positive FTA-Abs reactivity had similar degree of long-term metabolic control and prevalence of islet cell antibodies (ICA) as well as late diabetic complications as FTA-Abs negative diabetic patients, matched regarding to sex, age, type, and duration of diabetes. In conclusion, false-positive FTA-Abs reactivity is not rare in diabetic patients. The reason for this phenomenon is unknown, but could be a sign of autoimmunity of its own. Hence, in diabetic patients with FTA-Abs test indicating syphilis, the diagnosis must be verified with a combination of other tests.

引用

页码：57 / 62

页数：6

共 28 条

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