INHIBITION OF INTRACELLULAR ESTERASES BY ANTITUMOUR CHLOROETHYLNITROSOUREAS - MEASUREMENT BY FLOW-CYTOMETRY AND CORRELATION WITH MOLECULAR CARBAMOYLATION ACTIVITY

被引：11

作者：

DIVE, C ^{[1
]}

WORKMAN, P ^{[1
]}

WATSON, JV ^{[1
]}

机构：

[1] MRC,CLIN ONCOL & RADIOTHERAPEUT UNIT,HILLS RD,CAMBRIDGE,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1988年 / 37卷 / 20期

关键词：

D O I：

10.1016/0006-2952(88)90084-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：3987 / 3993

页数：7

共 41 条

[1]

ANDERSON T, 1975, CANCER RES, V35, P761

[2] ACTIVE-SITE SPECIFIC INACTIVATION OF CHYMOTRYPSIN BY CYCLOHEXYL ISOCYANATE FORMED DURING DEGRADATION OF CARCINOSTATIC 1-(2-CHLOROETHYL)-3-CYCLOHEXYL-1-NITROSOUREA [J].

BABSON, JR ;

REED, DJ ;

SINKEY, MA .

BIOCHEMISTRY, 1977, 16 (08) :1584-1589

[3] INACTIVATION OF GLUTATHIONE REDUCTASE BY 2-CHLOROETHYL NITROSOUREA-DERIVED ISOCYANATES [J].

BABSON, JR ;

REED, DJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (02) :754-762

[4]

BARIL BB, 1975, CANCER RES, V35, P1

[5] INHIBITION OF TUBULIN POLYMERIZATION BY NITROSOUREA-DERIVED ISOCYANATES [J].

BRODIE, AE ;

BABSON, JR ;

REED, DJ .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (04) :652-654

[6] ALKYL ISOCYANATES AS ACTIVE-SITE-SPECIFIC REAGENTS FOR SERINE PROTEASES - IDENTIFICATION OF ACTIVE-SITE SERINE AS SITE OF REACTION [J].

BROWN, WE ;

WOLD, F .

BIOCHEMISTRY, 1973, 12 (05) :835-840

[7] MEASUREMENT OF CARBAMOYLATING ACTIVITY OF NITROSOUREAS AND ISOCYANATES BY A NOVEL HIGH-PRESSURE LIQUID-CHROMATOGRAPHY ASSAY [J].

BRUBAKER, WF ;

ZHAO, HP ;

PRUSOFF, WH .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (14) :2359-2365

[8]

BYRNE P, 1984, BLOOD, V63, P759

[9]

CHENG CJ, 1972, CANCER RES, V32, P22

[10]

COLVIN M, 1981, NITROSOUREAS, P42

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