HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF TEXTROXOPRIM AND SULFADIAZINE IN SERUM AND URINE

被引：2

作者：

ALKAYSI, HN ^{[1
]}

SALEM, MS ^{[1
]}

BADWAN, AA ^{[1
]}

机构：

[1] JORDANIAN PHARMACEUT MFG CO,NAOR,JORDAN

来源：

BIOMEDICAL CHROMATOGRAPHY | 1991年 / 5卷 / 06期

关键词：

D O I：

10.1002/bmc.1130050608

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative determination of tetroxoprim and sulphadiazine in serum and urine was performed using reversed phase high performance liquid chromatography. Protein precipitation using 10% perchloric acid was utilized for purification of serum samples while urine samples were diluted prior to analysis. The mobile phase consisted of triethylammonium acetate buffer (85%), acetonitrile (12%) and methanol (3%), with a final pH of 4.2. The eluent was monitored at 280 nm. Benzoic acid was used as an internal standard. Standardization, validation and application of the method is described.

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页码：265 / 268

页数：4

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