CONTROL OF METALLOTHIONEIN EXPRESSION BY HORMONES AND STRESSORS IN CULTURED FISH CELL-LINES

被引:4
作者
BURGESS, D
FRERICHS, N
GEORGE, S
机构
[1] NERC Unit of Aquatic Biochemistry, School of Natural Sciences, University of Stirling, Stirling
关键词
D O I
10.1016/0141-1136(93)90008-N
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In-vitro studies with established cell lines from a marine flatfish (turbot) and an anadromous fish (rainbow trout) were used to study hormonal effects on metallothionein synthesis. Only the turbot cell line responded to glucocorticoid and progesterone treatments, with a 1.5-2-fold induction of MT levels. Neither cell line displayed a positive response to oestradiol, phorbol ester or bacterial endotoxin. A practical implication of these findings in use of fish-metallothionein levels for heavy-metal pollution monitoring is that sexually mature animals must not be used and levels less than 3-fold higher than reference sites, which may be due to hormonal effects, must be disregarded.
引用
收藏
页码:25 / 28
页数:4
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