RANDOMIZED PLACEBO-CONTROLLED TRIAL OF PRIMAQUINE FOR PROPHYLAXIS OF FALCIPARUM AND VIVAX MALARIA

被引:121
作者
FRYAUFF, DJ
BAIRD, JK
BASRI, H
SUMAWINATA, I
PURNOMO
RICHIE, TL
OHRT, CK
MOUZIN, E
CHURCH, CJ
RICHARDS, AL
SUBIANTO, B
SANDJAJA, B
WIGNALL, FS
HOFFMAN, SL
机构
[1] USN,MED RES UNIT 2,JAKARTA,INDONESIA
[2] TULANE UNIV,MED CTR,DEPT MED,NEW ORLEANS,LA 70112
[3] ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND
[4] PROV HLTH SERV,IRIAN JAYA,INDONESIA
[5] USN,MED RES INST,BETHESDA,MD
来源
LANCET | 1995年 / 346卷 / 8984期
关键词
D O I
10.1016/S0140-6736(95)92898-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Drug resistance has made malaria prevention difficult and the new agents are too expensive for widespread use, Primaquine, an established drug for treatment, is potentially useful for prevention, Malaria prophylaxis with primaquine was evaluated in Irian Jaya during one year in Javanese men who were not deficient in glucose-6-phosphate dehydrogenase (G-6-PD). 126 volunteers were randomised to receive 0 . 5 mg/hg primaquine base or placebo daily (double-blinded), or 300 mg chloroquine base weekly (open). The protective efficacy of primaquine relative to placebo was 94 . 5% (95% confidence interval 57-99) for Plasmodium falciparum and 90 . 4% (95% CI 58-98) for P vivax, Attack rates for either parasite did not differ significantly between the chloroquine and placebo groups. Incidence density of physical complaints not associated with parasitaemia was low (17-18 complaints/person-year) and was about the same in all groups except for cough, which was increased in the primaquine group. Complete blood counts were normal and no evidence of hepatic or renal dysfunction was found with primaquine. However, at 50 weeks the primaquine group had a mean methaemoglobin of 5 . 8% (range 1 . 4-13%), which declined by half within 7 days of ending prophylaxis. When used daily for one year by men with normal G-6-PD activity, primaquine was well tolerated and effective for prevention of malaria.
引用
收藏
页码:1190 / 1193
页数:4
相关论文
共 21 条
  • [1] ALVING AS, 1959, 6 P INT C TROP MED M, V7, P203
  • [2] ARNOLD J, 1955, J LAB CLIN MED, V46, P391
  • [3] RESISTANCE TO CHLOROQUINE BY PLASMODIUM-VIVAX IN IRIAN-JAYA, INDONESIA
    BAIRD, JK
    BASRI, H
    PURNOMO
    BANGS, MJ
    SUBIANTO, B
    PATCHEN, LC
    HOFFMAN, SL
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 44 (05) : 547 - 552
  • [4] BAIRD JK, 1995, AM J TROP MED HYG, V52, P497
  • [5] BAIRD JK, IN PRESS AM J TROP M
  • [6] BEUTLER E, 1983, HEMATOLOGY, P1632
  • [7] BLACK RH, 1981, WHO MONOGR SER, V27
  • [8] CARSON PE, 1984, HDB EXPT PHARM, V68, P83
  • [9] STATUS OF PRIMAQUINE .3. TOXICITY OF PRIMAQUINE IN CAUCASIANS
    CLAYMAN, CB
    ARNOLD, J
    HOCKWALD, RS
    YOUNT, EH
    EDGCOMB, JH
    ALVING, AS
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1952, 149 (17): : 1563 - 1568
  • [10] CLYDE DF, 1981, B WORLD HEALTH ORGAN, V59, P391