MICROBIAL HYDROLYSIS OF PEPSIDINES

被引：2

作者：

HASEGAWA, Y ^{[1
]}

NOZU, Y ^{[1
]}

KUWANA, N ^{[1
]}

机构：

[1] EISAI CO LTD, RES LAB, GIFU, JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1976年 / 40卷 / 03期

关键词：

D O I：

10.1080/00021369.1976.10862086

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Microbial hydrolysis of pepsidines was studied by using bacteria. A strain of bacteria which was isolated from soil and identified as Bacillus pumilus could release successively N-terminal acetyl moiety and valine from pepsidine C. The residual peptides thus obtained were crystallized and identified as desacyl-pepsidine and desacylvalyl-pepsidine. The correlation between their structures and pepsin inhibitory activities was also studied.

引用

收藏

页码：451 / 458

页数：8

相关论文

共 10 条

[1] NEW PEPSTATINS, PEPSTATINS BU, PR AND AC PRODUCED BY STREPTOMYCES [J].

AOYAGI, T ;

YAGISAWA, Y ;

KUMAGAI, M ;

HAMADA, M ;

MORISHIMA, H ;

TAKEUCHI, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1973, 26 (09) :539-541

[2] BIOLOGICAL-ACTIVITY OF PEPSTATINS, PEPSTANONE A AND PARTIAL PEPTIDES ON PEPSIN, CATHEPSIN D AND RENIN [J].

AOYAGI, T ;

MORISHIMA, H ;

NISHIZAWA, R ;

KUNIMOTO, S ;

TAKEUCHI, T ;

UMEZAWA, H ;

IKEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1972, 25 (12) :689-694

[3] STRUCTURE ELUCIDATION OF NEW PEPSIN INHIBITOR (S-PI) [J].

FUKUMURA, M ;

SATOI, S ;

KUWANA, N ;

MURAO, S .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1971, 35 (08) :1310-&

[4]

KIRYUSHKIN AA, 1966, TETRAHEDRON LETT, P33

[5]

KUWANA N, 1974, Patent No. 125583

[6] NEW PEPSTATINS, PEPSTATINS-B AND C, AND PEPSTANONE-A, PRODUCED BY STREPTOMYCES [J].

MIYANO, T ;

UMEZAWA, H ;

TAKITA, T ;

TOMIYASU, M ;

TOMISAKA, S ;

IIZUKA, H ;

AOYAGI, T .

JOURNAL OF ANTIBIOTICS, 1972, 25 (08) :489-&

[7] CHEMICAL SYNTHESIS OF PEPSTATIN-A [J].

MORISHIMA, H ;

TAKITA, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1972, 25 (09) :551-+

[8] NEW PEPSIN INHIBITORS (S-PI) FROM STREPTOMYCES EF-44-201 [J].

MURAO, S ;

SATOI, S .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1970, 34 (08) :1265-&

[9] A NEW METHOD FOR THE DETECTION OF PEPTIDES AND SIMILAR COMPOUNDS ON PAPER CHROMATOGRAMS [J].

RYDON, HN ;

SMITH, PWG .

NATURE, 1952, 169 (4309) :922-923

[10] PEPSTATIN, A NEW PEPSIN INHIBITOR PRODUCED BY ACTINOMYCETES [J].

UMEZAWA, H ;

AOYAGI, T ;

MORISHIMA, H ;

MATSUZAKI, M ;

HAMADA, M ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1970, 23 (05) :259-+