N-METHYL-D-ASPARTATE-INDUCED NEURONAL ACTIVATION IS SELECTIVELY MODULATED BY SIGMA-RECEPTORS

被引：233

作者：

MONNET, FP ^{[1
]}

DEBONNEL, G ^{[1
]}

JUNIEN, JL ^{[1
]}

DEMONTIGNY, C ^{[1
]}

机构：

[1] JOUVEINAL LABS,F-94263 FRESNES,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 179卷 / 03期

基金：

英国医学研究理事会;

关键词：

Hippocampus (dorsal); Kainate; NMDA (N-methyl-D-aspartate); Quisqualate; σReceptors;

D O I：

10.1016/0014-2999(90)90186-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of two high-affinity σ ligands, DTG (1,3-di(2-tolyl)guanidine) and haloperidol, on the activation of dorsal hippocampus pyramidal neurons induced by microiontopheretic application of N-methyl-D-aspartate (NMDA) were assessed electrophysiologically. Low doses of DTG (0.5-3 μg/kg i.v.) potentiated the NMDA response. This effect of DTG was blocked by haloperidol (10 μg/kg i.v.), but not by spiperone, a potent dopamine antagonist with low affinity for σ receptors. These results suggest that σ receptors modulate the NMDA-induced neuronal activation. © 1990.

引用

页码：441 / 445

页数：5

共 10 条

[1]

ARAM JA, 1989, J PHARMACOL EXP THER, V248, P320

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