2,4-DICHLOROPHENOXYACETIC ACID EFFECTS ON POLYAMINE BIOSYNTHESIS

被引：12

作者：

RIVAROLA, V ^{[1
]}

BALEGNO, H ^{[1
]}

机构：

[1] UNIV NACL RIO CUARTO,FAC CIENCIAS EXACTAS FIS QUIM & NAT,DEPT BIOL MOLEC,RUTA 8 KM 601,RA-5800 RIO CURATO,ARGENTINA

来源：

TOXICOLOGY | 1991年 / 68卷 / 02期

关键词：

2,4-DICHLOROPHENOXYACETIC ACID; POLYAMINES; CHO CELLS;

D O I：

10.1016/0300-483X(91)90014-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the Gl/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.

引用

页码：109 / 119

页数：11

共 10 条

[1] POLYAMINES AND THEIR ROLE IN PROTEIN-SYNTHESIS [J].