DELAYED CHANGES IN NEURAL VISININ-LIKE CALCIUM-BINDING PROTEIN GENE-EXPRESSION CAUSED BY ACUTE PHENCYCLIDINE ADMINISTRATION

被引：8

作者：

KAJIMOTO, Y

SHIRAKAWA, O

KUNO, T

NISHINO, N

NAKAI, H

机构：

[1] KOBE UNIV,SCH MED,DEPT NEUROL & PSYCHIAT,CHUO KU,KOBE 650,JAPAN

[2] KOBE UNIV,SCH MED,DEPT PHARMACOL,CHUO KU,KOBE 650,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1995年 / 100卷 / 03期

关键词：

PHENCYCLIDINE (PCP); NEURAL VISININ-LIKE CA2+-BINDING PROTEIN (NVP); GENE EXPRESSION; RAT; BRAIN; SCHIZOPHRENIA;

D O I：

10.1007/BF01276463

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca2+-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca2+-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.

引用

页码：257 / 262

页数：6

共 19 条

[1] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].