PASSIVE-IMMUNIZATION OF THE VAGINA PROTECTS MICE AGAINST VAGINAL TRANSMISSION OF GENITAL HERPES INFECTIONS

被引：60

作者：

WHALEY, KJ

ZEITLIN, L

BARRATT, RA

HOEN, TE

CONE, RA

机构：

[1] Department of Biophysics, Johns Hopkins University, Baltimore, MD

[2] Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 169卷 / 03期

关键词：

D O I：

10.1093/infdis/169.3.647

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaginal application of human herpes simplex virus (HSV) antiserum, complement-inactivated antiserum, or IgG purified from antiserum protected mice (P < .001, P < .001, and P < .01, respectively) from visible signs of genital HSV-2 infection after subsequent vaginal inoculation with HSV-2 (10 ID50). Vaginal application of an anti-HSV-2 monoclonal antibody (MAb III-174) also protected mice against infection. This MAb, a neutralizing mouse IgGZA against glycoprotein D, prevented infection as determined by viral shedding from the vagina (P < .05), blocked 50% of visible signs of genital herpes infection at a vaginal dose of similar to 10 ng, and blocked 100% of visible signs of infection at a vaginal dose of 1 mu g (P < .001). These results suggest that vaginal applications of anti-HSV antibodies may help prevent sexual transmission of genital herpes infection.

引用

页码：647 / 649

页数：3

共 13 条

[1] RESISTANCE OF FEMALE MICE TO VAGINAL INFECTION INDUCED BY HERPESVIRUS-HOMINIS TYPE 2 - EFFECTS OF IMMUNIZATION WITH MYCOBACTERIUM-BOVIS, INTRAVENOUS-INJECTION OF SPECIFIC HERPESVIRUS-HOMINIS TYPE 2 ANTISERUM, AND A COMBINATION OF THESE PROCEDURES [J].