BRUCEOSIDE-D, BRUCEOSIDE-E, AND BRUCEOSIDE-F, 3 NEW CYTOTOXIC QUASSINOID GLUCOSIDES FROM BRUCEA-JAVA']JAVANICA

被引：36

作者：

OHNISHI, S

FUKAMIYA, N

OKANO, M

TAGAHARA, K

LEE, KH

机构：

[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & SCI,DEPT INTERDISCIPLINARY STUDIES NAT ENVIRONM,HIGASHIHIROSHIMA 724,JAPAN

[2] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE 658,JAPAN

[3] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 07期

关键词：

D O I：

10.1021/np50121a007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI(50) values in the range of -4.14 to -5.72.

引用

页码：1032 / 1038

页数：7

共 13 条

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