EXTRACELLULAR CALCIUM CAUSES THE RELEASE OF CALCIUM FROM INTRACELLULAR STORES IN CHICK OSTEOCYTES

被引：20

作者：

KAMIOKA, H ^{[1
]}

MIKI, Y ^{[1
]}

SUMITANI, K ^{[1
]}

TAGAMI, K ^{[1
]}

TERAI, K ^{[1
]}

HOSOI, K ^{[1
]}

KAWATA, T ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH DENT,DEPT ORAL PHYSIOL,TOKUSHIMA 770,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently demonstrated that a rise in the extracellular divalent cation concentration induces a rapid elevation of cytosolic calcium in chick osteocytes. Here, we demonstrate that cytosolic calcium elevation that occurs in osteocytes on exposure to elevated extracellular calcium is independent of membrane voltage and is insensitive to modulation by organic calcium channel modulators, namely, BAY K 8644, nicardipine, and nifedipine. However, the calcium elevation was sensitive to modulation by an intracellular calcium antagonist, TMB-8, suggesting that the cytosolic calcium elevation was due to mobilization of this cation from an intracellular store. (C) 1995 Academic Press, Inc.

引用

页码：692 / 696

页数：5

共 12 条

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