COMBINED IMMUNOHISTOCHEMICAL STUDY OF TISSUE POLYPEPTIDE ANTIGEN AND CANCER ANTIGEN-125 IN HUMAN OVARIAN-TUMORS

被引：7

作者：

GHAZIZADEH, M ^{[1
]}

SASAKI, Y ^{[1
]}

OGURO, T ^{[1
]}

AIHARA, K ^{[1
]}

TENJIN, H ^{[1
]}

ARAKI, T ^{[1
]}

机构：

[1] NIPPON MED COLL,DEPT OBSTET & GYNAECOL,TOKYO 113,JAPAN

来源：

HISTOPATHOLOGY | 1990年 / 17卷 / 02期

关键词：

cancer antigen 125; carcinoma; immunohistochemistry; ovary; tissue polypeptide antigen;

D O I：

10.1111/j.1365-2559.1990.tb00682.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An indirect immunoperoxidase method was used to study the expression of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA 125) in 47 benign and malignant ovarian tumours. Tissue polypeptide antigen and CA 125 antigen were expressed respectively in 22 (73%) and 16 (53%) of the 30 adenocarcinomas and in five (29%) and four (23%) of the 17 benign tumours. Co‐expression of TPA and CA 125 antigen occurred in 12 (40%) malignant and four (23%) benign tumours. Ultrastructurally, TPA and CA 125 antigens were located at the cell surface and microvillous surfaces. Evaluation of combined TPA and CA 125 antigen results revealed a remarkable improvement in the positivity rate and a significant decrease (P<0.05) in the negativity rate of ovarian carcinomas as compared with the result of each one separately. These findings provide complementary evidence for the previous results on the plasma levels of TPA and CA 125 antigen and suggest that specific combinations of tumour markers may be more effective for the diagnosis and monitoring of ovarian carcinomas, than the use of any single marker. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：123 / 128

页数：6

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