EFFECT OF CYCLODEXTRIN ON THE PHARMACOLOGY OF ANTIFUNGAL ORAL AZOLES

被引：129

作者：

HOSTETLER, JS

HANSON, LH

STEVENS, DA

机构：

[1] CALIF INST MED RES,SAN JOSE,CA 95128

[2] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 02期

关键词：

D O I：

10.1128/AAC.36.2.477

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.

引用

页码：477 / 480

页数：4

共 10 条

[1]

BLUM RA, 1991, ANN INTERN MED, V114, P754

[2] DISPOSITION OF KETOCONAZOLE, AN ORAL ANTIFUNGAL, IN HUMANS [J].