SEROTONIN REGULATION OF TACHYKININ BIOSYNTHESIS IN THE RAT NEOSTRIATUM

被引：54

作者：

WALKER, PD ^{[1
]}

RILEY, LA ^{[1
]}

HART, RP ^{[1
]}

JONAKAIT, GM ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT BIOL SCI,NEW BRUNSWICK,NJ 08903

来源：

BRAIN RESEARCH | 1991年 / 546卷 / 01期

关键词：

PREPROTACHYKININ; SUBSTANCE-P; SEROTONIN; TACHYKININ; NEOSTRIATUM; MESSENGER RNA;

D O I：

10.1016/0006-8993(91)91155-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin (5-HT) neurotransmission was altered to determine its role in regulating the biosynthesis of tachykinins in the neostriatum (NS). Depletion of 5-HT with subchronic p-chlorophenylalanine (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS. By contrast, raising extracellular 5-HT levels with zimelidine (a 5-HT uptake inhibitor) or clorgyline (a monoamine oxidase inhibitor) resulted in increased levels of PPT mRNA. To determine whether 5-HT receptors played a role in mediating the changes in PPT mRNA, animals were treated with the 5-HT2 agonist DOI. This drug significantly increased both PPT mRNA and SP-like immunoreactivity in the NS. These results together indicate that neostriatal tachykinin biosynthesis is sensitive to alterations in 5-HT neurotransmission.

引用

页码：33 / 39

页数：7

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