INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REV FUNCTION BY A REV MUTANT WHICH INTERFERES WITH NUCLEAR NUCLEOLAR LOCALIZATION OF REV

被引：34

作者：

KUBOTA, S ^{[1
]}

FURUTA, R ^{[1
]}

MAKI, M ^{[1
]}

HATANAKA, M ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT MOLEC VIROL,HUMAN CANC LAB,KYOTO 606,JAPAN

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 04期

关键词：

D O I：

10.1128/JVI.66.4.2510-2513.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A nonfunctional mutant of human immunodeficiency virus type 1 Rev was created by deleting seven amino acid residues within the nucleolar targeting signal. This mutant Rev remained in the cytoplasm in expressed cells and strongly inhibited the function of Rev by interfering with the nuclear/nucleolar localization of coexpressed Rev. These findings strongly suggest the multimerization of Rev in the cytoplasm before migration to the nucleus/nucleolus, where wild-type Rev functions as a trans-regulator.

引用

页码：2510 / 2513

页数：4

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