STEVENS-JOHNSON-TYPE REACTION WITH VANCOMYCIN TREATMENT

被引:15
作者
LAURENCIN, CT
HORAN, RF
SENATUS, PB
WHEELER, CB
LIPSON, SJ
机构
[1] MASSACHUSETTS GEN HOSP, DEPT ORTHOPAED SURG, BOSTON, MA 02114 USA
[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[3] BRIGHAM & WOMENS HOSP, DEPT DERMATOL, BOSTON, MA 02115 USA
[4] BETH ISRAEL HOSP, DEPT ORTHOPAED SURG, BOSTON, MA 02215 USA
关键词
D O I
10.1177/106002809202601206
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVE: To report a case of Stevens-Johnson syndrome caused by vancomycin. CASE SUMMARY: Stevens-Johnson syndrome is an acute mucocutaneous process characterized by epidermal and mucosal desquamation. Its pathogenesis is poorly understood. Mortality rates have ranged from 30 to 100 percent. We describe a case of Stevens-Johnson syndrome related to the use of vancomycin in a 7 1 -year-old woman with rheumatoid arthritis receiving treatment for an infected cervical fusion site. Classic "target" lesions distributed throughout the trunk and extremities along with erosive lesions involving the oral and vaginal mucosae were observed in this patient. DISCUSSION: A number of agents have been implicated in the etiology of Stevens-Johnson syndrome. Serious cutaneous reactions to vancomycin, however, have been uncommon. Cessation of vancomycin treatment in our patient led to eventual resolution of her symptoms. CONCLUSIONS: Vancomycin is a potential causative agent of Stevens-Johnson syndrome.
引用
收藏
页码:1520 / 1521
页数:2
相关论文
共 20 条
[1]  
ASHBY DW, 1951, LANCET, V260, P1091
[2]   VANCOMYCIN-INDUCED LINEAR IGA BULLOUS DERMATOSIS [J].
BADEN, LA ;
APOVIAN, C ;
IMBER, MJ ;
DOVER, JS .
ARCHIVES OF DERMATOLOGY, 1988, 124 (08) :1186-1188
[3]   ERYTHEMA MULTIFORME - DIRECT IMMUNOFLUORESCENCE STUDIES AND DETECTION OF CIRCULATING IMMUNE-COMPLEXES [J].
BUSHKELL, LL ;
MACKEL, SE ;
JORDON, RE .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1980, 74 (05) :372-374
[4]  
ELIAS PM, 1987, DERMATOLOGY GENERAL, P555
[5]  
Fiessenger N., 1917, PARIS M D, V25, P54
[6]   VANCOMYCIN-ASSOCIATED EXFOLIATIVE DERMATITIS [J].
FORRENCE, EA ;
GOLDMAN, MP .
DICP-THE ANNALS OF PHARMACOTHERAPY, 1990, 24 (04) :369-371
[7]   VANCOMYCIN-ASSOCIATED EXFOLIATIVE DERMATITIS DURING CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS [J].
GUTFELD, MB ;
REDDY, PV ;
MORSE, GD .
DRUG INTELLIGENCE & CLINICAL PHARMACY, 1988, 22 (11) :881-882
[8]   VANCOMYCIN-INDUCED TOXIC EPIDERMAL NECROLYSIS [J].
HANNAH, BA ;
KIMMEL, PL ;
DOSA, S ;
TURNER, ML .
SOUTHERN MEDICAL JOURNAL, 1990, 83 (06) :720-722
[9]  
HEBRA F, 1866, NEW SYDENHAM SOC, V5, P1880
[10]   VANCOMYCIN-INDUCED VASCULITIS [J].
MARKMAN, M ;
LIM, HW ;
BLUESTEIN, HG .
SOUTHERN MEDICAL JOURNAL, 1986, 79 (03) :382-383