HYPERTHERMIA INDUCES 72KDA HEAT-SHOCK PROTEIN EXPRESSION IN RAT-BRAIN IN NONNEURONAL CELLS

被引：15

作者：

MCCABE, T ^{[1
]}

SIMON, RP ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO GEN HOSP,DEPT NEUROL,1001 POTRERO 4M62,SAN FRANCISCO,CA 94110

来源：

NEUROSCIENCE LETTERS | 1993年 / 159卷 / 1-2期

关键词：

HEAT SHOCK PROTEIN; STRESS PROTEIN; HYPERTHERMIA; ISCHEMIA; ISCHEMIC TOLERANCE; OLIGODENDROGLIA;

D O I：

10.1016/0304-3940(93)90824-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of the nonconstitutive 72 kDa heat shock protein (HSP) in the brains of rats 24 h following graded periods of hyperthermia was studied immunocytochemically. Hyperthermia induced HSP-72 diffusely in cells throughout the cortex, hippocampus and basal ganglia in a dose dependent manner. The cell morphology and location in white matter appeared non-neuronal. Following ischemia, neuronal HSP expression was prominent. These data raise questions regarding prior reports of hyperthermic induction of neuronal HSP expression and the potential pathogenesis of prior hyperthermia in protection against subsequent neuronal injury from ischemia.

引用

页码：163 / 165

页数：3

共 10 条

[1] HYPERTHERMIA PROTECTS AGAINST LIGHT DAMAGE IN THE RAT RETINA [J].