EXPRESSION AND REGULATION OF A GLUTAMATE-RECEPTOR SUBUNIT BY BFGF IN OLIGODENDROCYTE PROGENITORS

被引：41

作者：

GALLO, V ^{[1
]}

WRIGHT, P ^{[1
]}

MCKINNON, RD ^{[1
]}

机构：

[1] NINCDS,VIRAL & MOLEC PATHOGENESIS LAB,BETHESDA,MD 20892

来源：

GLIA | 1994年 / 10卷 / 02期

关键词：

O-2A PROGENITOR CELL; AMPA RECEPTORS; GLUTAMATE CHANNELS; GROWTH FACTORS;

D O I：

10.1002/glia.440100209

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oligodendrocyte progenitor cells (O-2A) express both kainate-preferring and AMPA-preferring glutamate receptors (Gallo et al., Sec. Neurosci. Abstr., 18:653, 1992b; Gallo et al., 1994). The expression and regulation of the GluR-4c, AMPA-preferring subunit by growth factors was studied by Northern blot analysis of total RNA from purified rat cortical O-2A progenitors. Differently from cortical neurons, O-2A progenitors only expressed two high molecular weight GluR-4c transcripts (6.2 and 4.2 kb), as observed also in cultured astrocytes. Basic fibroblast growth factor (bFGF) increased GluR-4c transcript levels in O-2A progenitors and its effects were not mimicked by platelet derived growth factor (PDGF) or fetal calf serum. Therefore, bFGF may regulate O-2A progenitor responsiveness to glutamate during development through the expression of glutamate receptor subunits. (C) 1994 Wiley-Liss, Inc.

引用

页码：149 / 153

页数：5

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