PROSTAGLANDIN-E(2) ANTAGONIZES GINGIVAL FIBROBLAST PROLIFERATION STIMULATED BY INTERLEUKIN-1-BETA

被引：11

作者：

ELATTAR, TMA

LIN, HS

机构：

[1] Laboratory of Hormone Research, University of Missouri-Kansas City Schools of Dentistry and Medicine, Kansas City

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 49卷 / 05期

关键词：

D O I：

10.1016/0952-3278(93)90208-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Treatment of human gingival fibroblasts with prostaglandin E2 (PGE2) resulted in significant concentration-dependent inhibition in deoxyribonucleic acid (DNA) synthesis (8.40-37.89%), while indomethacin (INDO) (PG inhibitor), interleukin-1beta (IL-1beta) or IL-1beta + INDO caused a significant and dose-dependent increase in DNA synthesis. Addition of PGE2 to culture media containing IL-1beta and INDO caused a significant concentration-dependent reduction in IL-1beta- and INDO-induced stimulation of DNA synthesis. The findings suggest that IL-1beta and PGE2, which are also produced by fibroblasts, could play an important role in regulation of gingival tissue development and wound healing, and their modulation may have therapeutic potential.

引用

页码：847 / 850

页数：4

共 42 条

[1]

FLURBIPROFEN EFFECT ON GINGIVAL CREVICULAR FLUID PROSTAGLANDIN AND THROMBOXANE LEVELS IN HUMANS [J].