FUNCTIONAL-HETEROGENEITY OF THE CAUDATE-PUTAMEN AS REVEALED BY C-FOS INDUCTION IN RESPONSE TO D1 RECEPTOR ACTIVATION

被引：7

作者：

ARNAULD, E

ARSAUT, J

DEMOTESMAINARD, J

机构：

[1] INSERM U. 176, Bordeaux

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 18卷 / 04期

关键词：

FOS; STRIATUM; DOPAMINE D1 RECEPTOR; DOPAMINE; HYBRIDIZATION;

D O I：

10.1016/0169-328X(93)90099-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SKF 38 393, a dopamine receptor agonist which stimulates the D1 receptor, has been shown to activate c-fos to a detectable level in rats only when the striatum has been sensitized by a previous 6-OHDA lesion of the nigrostriatal tract. In the present study, we reexamine the effect of SKF 38 393 by in situ hybridization in non-lesioned mice and show an induction of c-fos mRNA which is restricted to the ventricular edge and to the caudal part of the caudoputamen (CP) even with large doses of SKF 38 393. These results suggest a functional heterogeneity in the CP in response to dopaminergic drugs, which could reflect the anatomical or neurochemical heterogeneity of the striatum itself and its neuroanatomical connections.

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页码：339 / 342

页数：4

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