ALPHA-1-ADRENERGIC STIMULATION IS COUPLED TO CARDIAC MYOCYTE HYPERTROPHY

被引：78

作者：

IKEDA, U

TSURUYA, Y

YAGINUMA, T

机构：

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 260卷 / 03期

关键词：

ALPHA-1-RECEPTOR; CULTURE; C-MYC; CARDIAC MYOCYTE;

D O I：

10.1152/ajpheart.1991.260.3.H953

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We have investigated whether alpha-1-adrenergic stimulation is coupled to myocardial hypertrophy in adult rat ventricular cells (ARVC) in culture. Exposure of ARVC to norepinephrine (NE) caused a significant increase in [H-3]-leucine incorporation and total protein content in ARVC. Prazosin totally inhibited the NE-stimulated leucine uptake by ARVC. Inhibition of spontaneous contraction of ARVC with KCl or verapamil did not prevent the stimulation of hypertrophy by NE. Protooncogene c-myc expression in ARVC was induced at 1 h after exposure to NE. Above results support the premise that activation of the alpha-1-adrenergic receptors by NE induces hypertrophy of ARVC, independent of changes in contractile activity.

引用

页码：H953 / H956

页数：4

共 21 条

[1] DIFFERENTIATION OF ADULT-RAT CARDIAC MYOCYTES IN CELL-CULTURE [J].