DETERMINATION OF COW MILK FORMULA ALLERGENICITY IN THE RAT MODEL BY INVITRO MAST-CELL TRIGGERING AND INVIVO IGE INDUCTION

被引:47
作者
FRITSCHE, R
BONZON, M
机构
[1] Nestle Research Centre, Nestec Ltd
来源
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 93卷 / 04期
关键词
D O I
10.1159/000235256
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The allergenicity of cow milk formulas was assessed in vitro by their ability to trigger prelabelled H-3-serotonin release from normal rat mast cells sensitized passively with rat reaginic anti-cow milk protein antisera. It was found that enzymatically hydrolyzed milk formulas had 1,000 (BEBA(HA)) to over 100,000 (ALFARE) times lower mast cell-triggering capacities than a standard milk formula (NAN). In vivo, these hydrolyzed formulas induced 100 (BEBA(HA)) to 10,000 (ALFARE) times less IgE antibodies than the standard milk formula.
引用
收藏
页码:289 / 293
页数:5
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