DEPLETION OF HYPOTHALAMIC NOREPINEPHRINE AND SEROTONIN ENHANCES THE DEXAMETHASONE NEGATIVE FEEDBACK EFFECT ON ADRENOCORTICAL SECRETION

被引：25

作者：

FELDMAN, S ^{[1
]}

WEIDENFELD, J ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,IL-91010 JERUSALEM,ISRAEL

来源：

PSYCHONEUROENDOCRINOLOGY | 1991年 / 16卷 / 05期

关键词：

D O I：

10.1016/0306-4530(91)90004-D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of norepinephrine (NE) and serotonin (5-HT) in the negative feedback effect of dexamethasone (DEX) on the adrenocortical response to ether stress was investigated. Injection of the catecholamine neurotoxin, 6-hydroxydopamine, into the ventral noradrenergic bundle or the paraventricular nucleus of the hypothalamus (PVN) which produced a very significant depletion in hypothalamic NE content enhanced the negative feedback effect of DEX. Injection of the 5-HT neurotoxin, 5,7-dihydroxytryptamine, into the raphe nuclei or PVN, which caused a depletion of hypothalamic 5-HT, produced a similar effect on the adrenocortical response to DEX. The degree of negative feedback may be viewed as a balance of neural stimulatory and glucocorticoid influences of the hypothalamus. Thus the removal of the stimulatory effects of NE and 5-HT on adrenocortical secretion, by the neurotoxic lesions, enhanced the inhibitory influence of DEX.

引用

页码：397 / 405

页数：9

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