A ROLE FOR CILIARY NEUROTROPHIC FACTOR AS AN INDUCER OF REACTIVE GLIOSIS, THE GLIAL RESPONSE TO CENTRAL-NERVOUS-SYSTEM INJURY

被引：140

作者：

WINTER, CG ^{[1
]}

SAOTOME, Y ^{[1
]}

LEVISON, SW ^{[1
]}

HIRSH, D ^{[1
]}

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT ANAT & NEUROSCI,HERSHEY,PA 17033

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 13期

关键词：

D O I：

10.1073/pnas.92.13.5865

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Within the central nervous system (CNS) ciliary neurotrophic factor (CNTF) is expressed by astrocytes where it remains stored as an intracellular protein; its release and function as an extracellular ligand are thought to occur in the event of cellular injury. We find that overexpression of CNTF in transgenic mice recapitulates the glial response to CNS lesion, as does its injection into the uninjured brain. These results demonstrate that CNTF functions as an inducer of reactive gliosis, a condition associated with a number of neurological diseases of the CNS.

引用

页码：5865 / 5869

页数：5