17-BETA-ESTRADIOL STIMULATION OF ENDOTHELIAL K+ CHANNELS

被引：38

作者：

RUSKO, J

LI, L

VANBREEMEN, C

机构：

[1] Department of Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Whole-cell membrane current recordings under voltage clamp were made from freshly isolated rabbit aortic endothelial cells. Intracellular Ca2+ signals of fura-2 loaded both native single aortic endothelial cells and intact endothelium from rabbit cardiac valves were measured using imaging fluorescence microscopy. Application of 17-beta-estradiol stimulated rapid discharge of transient outward currents and induced an increase in the intracellular free Ca2+ concentration ([Ca2+](i). The stimulated discharge of outward currents and [Ca2+](i) were reduced by extracellulary applied tetraethylammonium (TEA). (C) 1995 Academic Press, Inc.

引用

页码：367 / 372

页数：6

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