SERUM MEASUREMENTS OF HUMAN NEUTROPHIL LIPOCALIN (HNL) DISCRIMINATE BETWEEN ACUTE BACTERIAL AND VIRAL-INFECTIONS

被引：137

作者：

XU, SY ^{[1
]}

PAUKSEN, K ^{[1
]}

VENGE, P ^{[1
]}

机构：

[1] UNIV UPPSALA HOSP,DEPT INFECT DIS,S-75185 UPPSALA,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1995年 / 55卷 / 02期

关键词：

C-REACTIVE PROTEIN; DIAGNOSIS; PREDICTIVE VALUE; RADIOIMMUNOASSAY; SENSITIVITY; SPECIFICITY;

D O I：

10.3109/00365519509089604

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Human neutrophil lipocalin (HNL) is a recently identified protein from human neutrophil granules. The concentrations of HNL in the circulation were measured, in a group of patients with acute infections, using a radioimmunoassay. The concentrations of HNL in patients infected by viruses and bacteria were 93.78+/-45.30 mu g 1(-1) (SD), 404.14 +/- 355.02 mu g 1(-1) (SD) in serum, and 47.81 +/- 18.18 mu g 1(-1) (SD), 145.46 +/- 194.32 mu g 1(-1) (SD) in plasma, respectively. The differences between the two patient groups were highly significant. There was a significant correlation between serum HNL and plasma HNL levels in bacterial infections (r=0.73, p<0.0001). The HNL serum levels also correlated with those of C-reactive protein(CRP) (r=0.59, p<0.0001). Determination of HNL in serum was more specific and sensitive than CRP in the distinction between viral and bacterial infections. At a cut-off of 155 mu g 1(-1) (HNL in serum), the positive and negative predictive values for the diagnosis of bacterial infections were 92 and 96%, respectively, which were superior to the optimal predictive values of CRP. Thus, the determination of HNL level is useful in the diagnosis of acute bacterial infections.

引用

页码：125 / 131

页数：7

共 21 条

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