NATIVE-LIKE AND STRUCTURALLY CHARACTERIZED DESIGNED ALPHA-HELICAL BUNDLES

被引：107

作者：

BETZ, SF

BRYSON, JW

DEGRADO, WF

机构：

[1] The DuPont Merck Pharmaceutical Company, Wilmington

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0959-440X(95)80029-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.

引用

页码：457 / 463

页数：7

共 34 条

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