RELAXATION OF HUMAN CORONARY-ARTERY AND ARTERIA MAMMALIA BY K+ -CHANNEL OPENERS

被引：4

作者：

BOSSALLER, C

AUCHSCHWELK, W

GRAF, K

GRAFE, M

CATADELGIRMEN, G

ENNKER, J

FLECK, E

机构：

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1992年 / 20卷

关键词：

HUMAN CORONARY ARTERY; HUMAN ARTERIA MAMMALIA; K+ -CHANNEL OPENERS; VASCULAR RELAXATION; NICORANDIL;

D O I：

10.1097/00005344-199206203-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three agents with K+-channel-opening activity-nicorandil, bimakalim (EMD 52692), and EMD 56431-were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 much greater than nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 much greater than nicorandil in human arteria mammaria. These data demonstrate that K+-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.

引用

页码：S13 / S16

页数：4

共 19 条

[1] IMPAIRED MUSCARINIC ENDOTHELIUM-DEPENDENT RELAXATION AND CYCLIC GUANOSINE 5'-MONOPHOSPHATE FORMATION IN ATHEROSCLEROTIC HUMAN CORONARY-ARTERY AND RABBIT AORTA
BOSSALLER, C
HABIB, GB
YAMAMOTO, H
WILLIAMS, C
WELLS, S
HENRY, PD
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) : 170 - 174
[2] THE PHARMACOLOGY OF POTASSIUM CHANNELS AND THEIR THERAPEUTIC POTENTIAL
COOK, NS
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (01) : 21 - 28
[3] HYPOXIC DILATION OF CORONARY-ARTERIES IS MEDIATED BY ATP-SENSITIVE POTASSIUM CHANNELS
DAUT, J
MAIERRUDOLPH, W
VONBECKERATH, N
MEHRKE, G
GUNTHER, K
GOEDELMEINEN, L
[J]. SCIENCE, 1990, 247 (4948) : 1341 - 1344
[4] DEGOUVILLE ACL, 1990, J PHARMACOL EXP THER, V252, P300
[5] THE ROLE OF ENDOTHELIUM IN THE RESPONSES OF VASCULAR SMOOTH-MUSCLE TO DRUGS
FURCHGOTT, RF
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1984, 24 : 175 - 197
[6] HAEUSLER G, 1990, CLIN PHYSIOL BIOCH, V8, P46
[7] CROMAKALIM, NICORANDIL AND PINACIDIL - NOVEL DRUGS WHICH OPEN POTASSIUM CHANNELS IN SMOOTH-MUSCLE
HAMILTON, TC
WESTON, AH
[J]. GENERAL PHARMACOLOGY, 1989, 20 (01): : 1 - 9
[8] EFFECTS OF NICORANDIL ON EXERCISE TOLERANCE IN PATIENTS WITH STABLE EFFORT ANGINA - A DOUBLE-BLIND-STUDY
HAYATA, N
ARAKI, H
NAKAMURA, M
[J]. AMERICAN HEART JOURNAL, 1986, 112 (06) : 1245 - 1250
[9] DUAL MECHANISM OF THE RELAXING EFFECT OF NICORANDIL BY STIMULATION OF CYCLIC-GMP FORMATION AND BY HYPERPOLARIZATION
KUKOVETZ, WR
HOLZMANN, S
BRAIDA, C
POCH, G
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1991, 17 (04) : 627 - 633
[10] STUDIES ON THE MECHANISM OF THE VASODILATOR ACTION OF NICORANDIL
LEFER, DJ
LEFER, AM
[J]. LIFE SCIENCES, 1988, 42 (19) : 1907 - 1914

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