COMPLEX TRANSLOCATION INVOLVING PH CHROMOSOME IN A PATIENT WITH TYPICAL CHRONIC MYELOGENOUS LEUKEMIA

被引：7

作者：

CALABRESE, G

PALKA, G

WESTBROOK, CA

SHEER, D

机构：

[1] UNIV CHIETI,INST BIOL & GENET,CHIETI,ITALY

[2] UNIV CHICAGO,MED CTR,DEPT MED,HEMATOL ONCOL SECT,CHICAGO,IL 60637

[3] IMPERIAL CANC RES FUND,HUMAN CYTOGENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 63卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90064-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a cytogenetic study of a patient with chronic myelogenous leukemia (CML) who, while displaying a Philadelphia (Ph) chromosome, resulting from a standard t(9;22) at diagnosis, during the chronic phase (CP) showed disappearance of the Ph and occurrence of new chromosome changes, including a marker probably arising from a translocation involving chromosome 17 and the Ph. In situ hybridization confirmed the cytogenetic appearance and demonstrated that the breakpoint on the Ph marker occurred below the BCR-ABL fusion gene.

引用

收藏

页码：52 / 55

页数：4

相关论文

共 16 条

[1] CHROMOSOMAL INSITU HYBRIDIZATION AND SOUTHERN BLOT ANALYSES USING C-ABL, C-SIS, OR BCR PROBE IN CHRONIC MYELOGENOUS LEUKEMIA-CELLS WITH VARIANT PHILADELPHIA TRANSLOCATIONS [J].

ABE, S ;

MINAMIHISAMATSU, M ;

ISHIHARA, T ;

SASAKI, M .

CANCER GENETICS AND CYTOGENETICS, 1989, 38 (01) :61-74

[2] TRANSLOCATION OF C-ABL TO MASKED PH IN CHRONIC MYELOID-LEUKEMIA [J].

HAGEMEIJER, A ;

DEKLEIN, A ;

GODDESALZ, E ;

TURCCAREL, C ;

SMIT, EME ;

VANAGTHOVEN, AJ ;

GROSVELD, GC .

CANCER GENETICS AND CYTOGENETICS, 1985, 18 (02) :95-104

[3] IS THE CHROMOSOMAL REGION 9Q34 ALWAYS INVOLVED IN VARIANTS OF THE PH1 TRANSLOCATION [J].

HAGEMEIJER, A ;

BARTRAM, CR ;

SMIT, EME ;

VANAGTHOVEN, AJ ;

BOOTSMA, D .

CANCER GENETICS AND CYTOGENETICS, 1984, 13 (01) :1-16

[4] LOCALIZATION OF THE C-ABL ONCOGENE ADJACENT TO A TRANSLOCATION BREAK POINT IN CHRONIC MYELOCYTIC-LEUKEMIA [J].

HEISTERKAMP, N ;

STEPHENSON, JR ;

GROFFEN, J ;

HANSEN, PF ;

DEKLEIN, A ;

BARTRAM, CR ;

GROSVELD, G .

NATURE, 1983, 306 (5940) :239-242

[5] THE PHILADELPHIA-CHROMOSOME - CONSIDERATIONS BASED ON STUDIES OF VARIANT PH TRANSLOCATIONS [J].

ISHIHARA, T ;

MINAMIHISAMATSU, M .

CANCER GENETICS AND CYTOGENETICS, 1988, 32 (01) :75-92

[6]

KELMAN Z, 1989, BLOOD, V74, P2318

[7]

MASHAL R, 1990, BLOOD, V75, P180

[8] COMPLEX TRANSLOCATIONS IN A PATIENT WITH CHRONIC MYELOCYTIC-LEUKEMIA - T(9-22-17) AND T(10-18-19) AFTER 2 FAILED BONE-MARROW TRANSPLANTATIONS [J].

MELNYK, A ;

KOWALVERN, A .

CANCER GENETICS AND CYTOGENETICS, 1990, 46 (01) :83-87

[9] TRANSPOSITION OF BREAKPOINT CLUSTER REGION (3' BCR) IN CML-CELLS WITH VARIANT PHILADELPHIA TRANSLOCATIONS [J].

OHYASHIKI, K ;

OHYASHIKI, JH ;

KINNIBURGH, AJ ;

ROWE, J ;

MILLER, KB ;

RAZA, A ;

PREISLER, HD ;

SANDBERG, AA .

CANCER GENETICS AND CYTOGENETICS, 1987, 26 (01) :105-115

[10] DETECTION OF BCR-ABL FUSION IN CHRONIC MYELOGENEOUS LEUKEMIA BY INSITU HYBRIDIZATION [J].

TKACHUK, DC ;

WESTBROOK, CA ;

ANDREEFF, M ;

DONLON, TA ;

CLEARY, ML ;

SURYANARAYAN, K ;

HOMGE, M ;

REDNER, A ;

GRAY, J ;

PINKEL, D .

SCIENCE, 1990, 250 (4980) :559-562