INTERACTION OF A NUCLEAR FACTOR-1-LIKE PROTEIN WITH A CAMP RESPONSE ELEMENT-BINDING PROTEIN IN RAT-LIVER

被引：11

作者：

LU, GH

SCHLICHTER, D

WICKS, WD

机构：

[1] UNIV TENNESSEE,DEPT BIOCHEM,KNOXVILLE,TN 37996

[2] LANZHOU UNIV,DEPT BIOL,LANZHOU,PEOPLES R CHINA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 03期

关键词：

D O I：

10.1016/0020-711X(92)90039-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The existence of both cAMP-responsive element binding factor and a nuclear factor 1-like (NF-1-like) protein in nuclear extracts from liver of cAMP-treated rat has been revealed. 2. Binding of these proteins to a DNA fragment containing both elements was cooperative, and 50% binding was achieved with considerably less protein than with a fragment bearing either element alone. 3. Cleavage of the fragment between the two elements abolished the apparent cooperative interaction. 4. Southwestern blot analysis showed that the NF-1-like protein has a molecular weight in the 28-30-kDa range. 5. The NF-1-like binding activity was very stable.

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页码：455 / 464

页数：10

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