FLOW MODULATES CORONARY VENULAR PERMEABILITY BY A NITRIC OXIDE-RELATED MECHANISM

被引:142
作者
YUAN, Y [1 ]
GRANGER, HJ [1 ]
ZAWIEJA, DC [1 ]
CHILIAN, WM [1 ]
机构
[1] TEXAS A&M UNIV SYST,HLTH SCI CTR,MICROCIRCULAT RES INST,COLL STN,TX 77843
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 263卷 / 02期
关键词
CORONARY MICROCIRCULATION; EXCHANGE VESSELS; APPARENT PERMEABILITY COEFFICIENT; N(G)-MONOMETHYL-L-ARGININE; L-ARGININE;
D O I
10.1152/ajpheart.1992.263.2.H641
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This study demonstrates that flow velocity modulates coronary venular permeability to albumin. Apparent permeability coefficients of albumin (P(a)) were measured in isolated cannulated coronary venules ranging from 30 to 70-mu-m in diameter. Hydrostatic and oncotic pressures were controlled while the intraluminal flow velocity was varied. P(a) at an intraluminal hydrostatic pressure of 12 cmH2O and a flow velocity of 7 mm/s was 4.01 +/-0.53 x 10(-6) cm/s. Increasing flow velocity to 10 and 13 mm/s augmented the permeability by 33 +/- 14 and 48 +/- 14%, respectively. The nitric oxide synthase inhibitor, N(G)-monomethyl-L-arginine (L-NMMA) (10(-5) M), decreased baseline P(a) and abolished the flow-induced permeability changes. Administration of L-arginine (3 x 10(-3) M), a physiological precursor of nitric oxide which reverses the effect of L-NMMA, restored the relationship between flow and permeability. From these results we conclude that 1) flow velocity should be considered as a physical force that potentially modulates permeability of venular exchange vessels in the heart and 2) flow modulates coronary venular permeability via the production of nitric oxide.
引用
收藏
页码:H641 / H646
页数:6
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