SYNTHESIS OF 2',3'-DIDEOXY-3',4'-DIHYDROXYMETHYL SUBSTITUTED PYRIMIDINE NUCLEOSIDE ANALOGS

被引：3

作者：

BJORSNE, M

CLASSON, B

KERS, I

SAMUELSSON, B

KVARNSTROM, I

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-43183 LINKOPING,SWEDEN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00454-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues have been synthesised using an aldol condensation followed by in situ cross Canizzaro reduction in order to introduce the 4′-hydroxymethyl group. Glycosylation using silylated pyrimidine bases furnished the 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues. © 1994.

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页码：43 / 46

页数：4

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