A NEW MEMBER OF THE INSULIN-RECEPTOR FAMILY, INSULIN RECEPTOR-RELATED RECEPTOR, IS EXPRESSED PREFERENTIALLY IN THE KIDNEY

被引：27

作者：

KURACHI, H

JOBO, K

OHTA, M

KAWASAKI, T

ITOH, N

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOL CHEM,KYOTO 60601,JAPAN

[2] UTANO NATL HOSP,CLIN RES CTR,KYOTO 616,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91287-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Shier and Watt isolated human and guinea pig genomic DNA encoding a putative protein, insulin receptor-related receptor (IRR), the primary structure of which is similar to that of other members of the insulin receptor family, the insulin receptor and type-I IGF receptor (J.Biol.Chem. 264, 14605-14608 (1989)). However, the expression of the IRR gene remained unknown. In this paper, we isolated the IRR cDNA from the rat brain and examined the expression of the IRR mRNA in a variety of rat tissues, including the brain, heart, lung, liver, small intestine, kidney, thymus, spleen, muscle, adipose tissue and cartilage by polymerase chain reaction. In contrast to the wide distribution of the insulin receptor and type-I IGF receptor mRNAs, the IRR mRNA is expressed preferentially in the kidney, which indicates that IRR has unique functions as a member of the insulin receptor family. © 1992.

引用

页码：934 / 939

页数：6

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