THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS CONTAINS ANOTHER B-CELL-SPECIFIC 3' ENHANCER CLOSE TO THE ALPHA-CONSTANT REGION

被引：94

作者：

MATTHIAS, P

BALTIMORE, D

机构：

[1] FRIEDRICH MIESCHER INST,CH-4002 BASEL,SWITZERLAND

[2] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1993年 / 13卷 / 03期

关键词：

D O I：

10.1128/MCB.13.3.1547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription of immunoglobulin genes is controlled by variable region promoters and by enhancers, both of which are lymphoid specific. Because immunoglobulin genes are subject to an extremely complex regulation, we anticipated that there might be additional control elements for these genes. We therefore sought additional enhancers and demonstrate here that there is indeed another weak transcriptional enhancer just 3' to the mouse alpha constant region. This novel immunoglobulin enhancer is lymphoid specific and at two positions can bind members of the Oct family of transcription factors.

引用

收藏

页码：1547 / 1553

页数：7

相关论文

共 47 条

[1] DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE [J].

ALT, FW ;

BLACKWELL, TK ;

YANCOPOULOS, GD .

SCIENCE, 1987, 238 (4830) :1079-1087

[2]

AUSUBEL FM, 1990, CURRENT PROTOCOLS MO

[3] A LYMPHOCYTE-SPECIFIC CELLULAR ENHANCER IS LOCATED DOWNSTREAM OF THE JOINING REGION IN IMMUNOGLOBULIN HEAVY-CHAIN GENES [J].

BANERJI, J ;

OLSON, L ;

SCHAFFNER, W .

CELL, 1983, 33 (03) :729-740

[4] RECOMBINATION BETWEEN IMMUNOGLOBULIN VARIABLE REGION GENE SEGMENTS IS ENHANCED BY TRANSCRIPTION [J].

BLACKWELL, TK ;

MOORE, MW ;

YANCOPOULOS, GD ;

SUH, H ;

LUTZKER, S ;

SELSING, E ;

ALT, FW .

NATURE, 1986, 324 (6097) :585-589

[5] THE B-CELL-SPECIFIC OCT-2 PROTEIN CONTAINS POU BOX-TYPE AND HOMEO BOX-TYPE DOMAINS [J].

CLERC, RG ;

CORCORAN, LM ;

LEBOWITZ, JH ;

BALTIMORE, D ;

SHARP, PA .

GENES & DEVELOPMENT, 1988, 2 (12A) :1570-1581

[6] THE MOUSE IGH 3'-ENHANCER [J].

DARIAVACH, P ;

WILLIAMS, GT ;

CAMPBELL, K ;

PETERSSON, S ;

NEUBERGER, MS .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (06) :1499-1504

[7] CORRECT TRANSCRIPTION OF AN IMMUNOGLOBULIN-K GENE REQUIRES AN UPSTREAM FRAGMENT CONTAINING CONSERVED SEQUENCE ELEMENTS [J].

FALKNER, FG ;

ZACHAU, HG .

NATURE, 1984, 310 (5972) :71-74

[8] PURIFICATION AND CHARACTERIZATION OF OTF-1, A TRANSCRIPTION FACTOR REGULATING CELL-CYCLE EXPRESSION OF A HUMAN HISTONE H2B GENE [J].

FLETCHER, C ;

HEINTZ, N ;

ROEDER, RG .

CELL, 1987, 51 (05) :773-781

[9] THE FOS COMPLEX AND FOS-RELATED ANTIGENS RECOGNIZE SEQUENCE ELEMENTS THAT CONTAIN AP-1 BINDING-SITES [J].

FRANZA, BR ;

RAUSCHER, FJ ;

JOSEPHS, SF ;

CURRAN, T .

SCIENCE, 1988, 239 (4844) :1150-1153

[10] CELL TYPE-SPECIFICITY ELEMENTS OF THE IMMUNOGLOBULIN HEAVY-CHAIN GENE ENHANCER [J].

GERSTER, T ;

MATTHIAS, P ;

THALI, M ;

JIRICNY, J ;

SCHAFFNER, W .

EMBO JOURNAL, 1987, 6 (05) :1323-1330

← 1 2 3 4 5 →