STEREOCHEMICAL CONTROL (E/Z AND SYN ANTI) BY THE DIPHENYLPHOSPHINOYL GROUP IN THE SYNTHESIS OF ALLYLIC ALCOHOLS BY ALLYLIC REARRANGEMENT AND BY 1,4-DIASTEREOSELECTIVE REDUCTION OF ENONES

被引：10

作者：

CLAYDEN, J

COLLINGTON, EW

ELLIOTT, J

MARTIN, SJ

MCELROY, AB

WARREN, S

WATERSON, D

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 16期

关键词：

D O I：

10.1039/p19930001849

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylic rearrangement of substitued 2-hydroxyalk-3-en-1-yl(diphenyl)phosphine oxides to 4-hydroxyalk-2-en-1-yl(diphenyl)phosphine oxides can be performed with total regio- and reasonable stereochemical control. Alternatively, the reduction of substituted 4-diphenylphosphinoylbut-2-en-1-ones shows remarkable 1,4-diastereoselectivity. All these reactions are directed by the diphenylphosphinoyl (Ph2PO) group.

引用

页码：1849 / 1859

页数：11

共 41 条

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