A GENE FOR A LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN IN THE NEMATODE CAENORHABDITIS-ELEGANS

被引：108

作者：

YOCHEM, J ^{[1
]}

GREENWALD, I ^{[1
]}

机构：

[1] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 10期

关键词：

D O I：

10.1073/pnas.90.10.4572

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A >23-kb gene that encodes a large integral membrane protein with a predicted structure similar to that of the low density lipoprotein (LDL) receptor-related protein (LRP) of mammals has been isolated and sequenced from the free-living nematode Caenorhabditis elegans. The 4753-amino acid predicted C. elegans product shares a nearly identical number and arrangement of amino acid sequence motifs with human LRP, and several exons of the C. elegans LRP gene correspond to exons of related parts of the human LDL receptor gene. The existence of an apparent homolog of LRP in C. elegans offers the possibility of genetic analysis of the in vivo roles of LRP and of the relationship between protein structure and function in a simple model organism.

引用

页码：4572 / 4576

页数：5

共 48 条

[1] ARMSTRONG PB, 1991, J BIOL CHEM, V266, P2526
[2] TRANSCRIPT ANALYSIS OF GLP-1 AND LIN-12, HOMOLOGOUS GENES REQUIRED FOR CELL-INTERACTIONS DURING DEVELOPMENT OF C-ELEGANS
AUSTIN, J
KIMBLE, J
[J]. CELL, 1989, 58 (03) : 565 - 571
[3] STRUCTURE AND FUNCTION OF A LIPOPROTEIN - LIPOVITELLIN
BANASZAK, L
SHARROCK, W
TIMMINS, P
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1991, 20 : 221 - 246
[4] THE LDL RECEPTOR RELATED PROTEIN, LRP, IS AN APOLIPOPROTEIN-E-BINDING PROTEIN
BEISIEGEL, U
WEBER, W
IHRKE, G
HERZ, J
STANLEY, KK
[J]. NATURE, 1989, 341 (6238) : 162 - 164
[5] BROWN MS, 1991, CURR OPIN LIPIDOL, V2, P65
[6] LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN ALPHA-2-MACROGLOBULIN RECEPTOR IS AN HEPATIC RECEPTOR FOR TISSUE-TYPE PLASMINOGEN-ACTIVATOR
BU, GJ
WILLIAMS, S
STRICKLAND, DK
SCHWARTZ, AL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) : 7427 - 7431
[7] CHATELET F, 1986, AM J PATHOL, V122, P512
[8] CHEN WJ, 1990, J BIOL CHEM, V265, P3116
[9] CHITWOOD DJ, 1987, ACS SYM SER, V325, P200
[10] INSERTION OF PART OF AN INTRON INTO THE 5' UNTRANSLATED REGION OF A CAENORHABDITIS-ELEGANS GENE CONVERTS IT INTO A TRANS-SPLICED GENE
CONRAD, R
THOMAS, J
SPIETH, J
BLUMENTHAL, T
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (04) : 1921 - 1926

← 1 2 3 4 5 →