HUMAN ADIPOCYTE APOPTOSIS OCCURS IN MALIGNANCY

被引：75

作者：

PRINS, JB ^{[1
]}

WALKER, NI ^{[1
]}

WINTERFORD, CM ^{[1
]}

CAMERON, DP ^{[1
]}

机构：

[1] UNIV QUEENSLAND, SCH MED, DEPT PATHOL, HERSTON, QLD 4006, AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2711

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid weight toss is frequently seen in malignancy. This weight loss is considered to result from enhanced lipolysis. Here, we show that adipocyte deletion by apoptosis, demonstrated by electron microscopy and DNA gel electrophoresis, occurs in some patients. Adipocyte apoptosis could not be demonstrated in patients without malignancy. These findings suggest that fat cell loss by apoptosis plays a role in malignancy-associated weight loss. (C) 1994 Academic Press, Inc.

引用

页码：625 / 630

页数：6

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