RESOLUTION OF THE 7 ISOMERIC RING-HYDROXYLATED PROPRANOLOLS AS TERT-BUTYLDIMETHYLSILYL DERIVATIVES BY CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：6

作者：

BALLARD, KD ^{[1
]}

KNAPP, DR ^{[1
]}

OATIS, JE ^{[1
]}

WALLE, T ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT PHARMACOL,CHARLESTON,SC 29425

来源：

JOURNAL OF CHROMATOGRAPHY | 1983年 / 277卷 / OCT期

关键词：

D O I：

10.1016/S0378-4347(00)84854-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

引用

页码：333 / 339

页数：7

共 10 条

[1] METABOLISM OF PROPRANOLOL (INDERAL) A POTENT SPECIFIC BETA-ADRENERGIC RECEPTOR BLOCKING AGENT [J].

BOND, PA .

NATURE, 1967, 213 (5077) :721-&

[2]

HAYES A, 1971, J PHARMACOL EXP THER, V176, P302

[3]

KNAPP DR, 1979, HDB ANAL DERIVATIZAT, P87

[4]

KUTSCHINSKI J, 1974, THESIS U CALIFORNIA

[5] N-METHYL-N-(TERT-BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE AND RELATED N-TERT-BUTYLDIMETHYLSILYL AMIDES AS PROTECTIVE SILYL DONORS [J].

MAWHINNEY, TP ;

MADSON, MA .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (17) :3336-3339

[6] RING-HYDROXYLATED PROPRANOLOL - SYNTHESIS AND BETA-RECEPTOR ANTAGONIST AND VASODILATING ACTIVITIES OF THE 7 ISOMERS [J].

OATIS, JE ;

RUSSELL, MP ;

KNAPP, DR ;

WALLE, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (03) :309-314

[7]

PATTERSON JW, 1970, PHARMACOL CLIN, V2, P127

[8] RAT-LIVER MICROSOMAL METABOLISM OF PROPRANOLOL - IDENTIFICATION OF 7 METABOLITES BY GAS CHROMATOGRAPHY MASS SPECTROMETRY [J].

TINDELL, GL ;

WALLE, T ;

GAFFNEY, TE .

LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1972, 11 (21) :1029-&

[9]

WALLE T, 1982, DRUG METAB DISPOS, V10, P122

[10]

WALLE T, 1972, J PHARMACOL EXP THER, V182, P83

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