BIOSYNTHETIC GROWTH-HORMONE CHANGES THE COLLAGEN AND ELASTIN CONTENTS AND BIOMECHANICAL PROPERTIES OF THE RAT AORTA

被引:22
作者
BRUEL, A
OXLUND, H
机构
来源
ACTA ENDOCRINOLOGICA | 1991年 / 125卷 / 01期
关键词
D O I
10.1530/acta.0.1250049
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The biomechanical and biochemical properties of aortas from female rats treated with biosynthetic human GH (b-hGH) for 80 days were investigated. b-hGH was administered at a dose of 5 mg.kg-1.d-1. Treatment with b-hGH increased the body weight by 75% and the diameter of the aorta by 14% compared with the control group. The concentration of collagen and the relative amount of collagen type I were increased, and the concentration of elastin was decreased. Aortas from the b-hGH-treated group showed increased extensibility in the regions corresponding to physiological load values (i.e. 100-200 mmHg), and increased stiffness in regions with higher load values. The increased extensibility at low load values corresponds well with the loss of elastin, and the increased stiffness at higher load values with the increased of collagen and relative increase of collagen type 1. These alterations induced by the growth hormone treatment might influence the elasticity and recoiling properties of the aorta.
引用
收藏
页码:49 / 57
页数:9
相关论文
共 39 条
  • [1] EPIDEMIOLOGY OF ACROMEGALY IN THE NEWCASTLE REGION
    ALEXANDER, L
    APPLETON, D
    HALL, R
    ROSS, WM
    WILKINSON, R
    [J]. CLINICAL ENDOCRINOLOGY, 1980, 12 (01) : 71 - 79
  • [2] BAK B, 1988, ACTA ORTHOP SCA S227, V59, P10
  • [3] BAK B, 1991, CLIN ORTHOPAEDICS, V226, P55
  • [4] BARNES MJ, 1988, COLLAGEN, V1, P275
  • [5] BENGTSSON BA, 1988, ACTA MED SCAND, V223, P327
  • [6] COLLAGEN FIBRILLOGENESIS INSITU - DISCONTINUOUS SEGMENTAL ASSEMBLY IN EXTRACELLULAR COMPARTMENTS
    BIRK, DE
    ZYCBAND, EI
    WINKELMANN, DA
    TRELSTAD, RL
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 580 : 176 - 194
  • [7] GROWTH-HORMONE SECRETORY PROFILES IN CONSCIOUS FEMALE RATS
    CLARK, RG
    CARLSSON, LMS
    ROBINSON, ICAF
    [J]. JOURNAL OF ENDOCRINOLOGY, 1987, 114 (03) : 399 - 407
  • [8] METABOLIC EFFECTS OF RECOMBINANT HUMAN GROWTH-HORMONE - ISOTOPIC STUDIES IN THE POSTABSORPTIVE STATE AND DURING TOTAL PARENTERAL-NUTRITION
    DOUGLAS, RG
    HUMBERSTONE, DA
    HAYSTEAD, A
    SHAW, JHF
    [J]. BRITISH JOURNAL OF SURGERY, 1990, 77 (07) : 785 - 790
  • [9] EPSTEIN EH, 1975, J BIOL CHEM, V250, P9304
  • [10] TYPE-I AND TYPE-III COLLAGEN INTERACTIONS DURING FIBRILLOGENESIS
    FLEISCHMAJER, R
    PERLISH, JS
    BURGESON, RE
    SHAIKHBAHAI, F
    TIMPL, R
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 580 : 161 - 175