SEX-DIFFERENCES IN ADRENAL AND HEPATIC ALPHA-TOCOPHEROL CONCENTRATIONS IN RATS

被引：7

作者：

FEINGOLD, IB ^{[1
]}

COLBY, HD ^{[1
]}

机构：

[1] PHILADELPHIA COLL PHARM & SCI,DEPT PHARMACOL & TOXICOL,WOODLAND AVE & 43RD ST,PHILADELPHIA,PA 19104

来源：

PHARMACOLOGY | 1992年 / 44卷 / 02期

关键词：

ALPHA-TOCOPHEROL; ADRENAL; HEPATIC; SEX DIFFERENCES; ANTIOXIDANTS;

D O I：

10.1159/000138880

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies were done to determine whether there were differences in adrenal or hepatic concentrations of alpha-tocopherol in male versus female rats. Alpha-Tocopherol levels were far greater in adrenal glands and livers from females than from males. There was no sex difference in the subcellular distribution of a-tocopherol in either organ, but alpha-tocopherol concentrations were generally greater in all subcellular fractions from females. Mitochondrial fractions contained approximately 50% of the total adrenal and hepatic alpha-tocopherol content. The results suggest that alpha-tocopherol concentrations in rat adrenals and livers are controlled, at least partly, by the gonadal hormones.

引用

页码：113 / 116

页数：4

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