HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES IN HEALTHY-CHILDREN AFTER ONE OR 2 DOSES OF VARICELLA VACCINE

被引：56

作者：

WATSON, B ^{[1
]}

BOARDMAN, C ^{[1
]}

LAUFER, D ^{[1
]}

PIERCY, S ^{[1
]}

TUSTIN, N ^{[1
]}

OLALEYE, D ^{[1
]}

CNAAN, A ^{[1
]}

STARR, SE ^{[1
]}

机构：

[1] CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,DIV BIOSTAT & EPIDEMIOL,PHILADELPHIA,PA

来源：

CLINICAL INFECTIOUS DISEASES | 1995年 / 20卷 / 02期

关键词：

D O I：

10.1093/clinids/20.2.316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.

引用

页码：316 / 319

页数：4

共 13 条

[1] LIVE ATTENUATED VARICELLA VACCINE - IMMUNIZATION OF HEALTHY-CHILDREN WITH THE OKA STRAIN
ARBETER, AM
STARR, SE
WEIBEL, RE
PLOTKIN, SA
[J]. JOURNAL OF PEDIATRICS, 1982, 100 (06) : 886 - 893
[2] VARICELLA VACCINE TRIALS IN HEALTHY-CHILDREN - A SUMMARY OF COMPARATIVE AND FOLLOW-UP STUDIES
ARBETER, AM
STARR, SE
PREBLUD, SR
IHARA, T
PACIOREK, PM
MILLER, DS
ZELSON, CM
PROCTOR, EA
PLOTKIN, SA
[J]. AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1984, 138 (05): : 434 - 438
[3] CELL-MEDIATED-IMMUNITY TO VARICELLA-ZOSTER VIRUS
ARVIN, AM
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 166 : S35 - S41
[4] ASANO Y, 1985, PEDIATRICS, V75, P667
[5] IMMUNITY TO WHOLE VARICELLA-ZOSTER VIRUS-ANTIGEN AND GLYCOPROTEIN-I AND GLYCOPROTEIN-P170 - RELATION TO THE IMMUNIZING REGIMEN OF LIVE ATTENUATED VARICELLA VACCINE
DIAZ, PS
SMITH, S
HUNTER, E
ARVIN, AM
[J]. JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (06) : 1245 - 1252
[6] COST-EFFECTIVENESS OF A ROUTINE VARICELLA VACCINATION PROGRAM FOR UNITED-STATES CHILDREN
LIEU, TA
COCHI, SL
BLACK, SB
HALLORAN, ME
SHINEFIELD, HR
HOLMES, SJ
WHARTON, M
WASHINGTON, AE
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (05): : 375 - 381
[7] PREBLUD SR, 1986, PEDIATRICS, V78, P728
[8] PERSISTENCE OF CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES IN HEALTHY-CHILDREN IMMUNIZED WITH LIVE ATTENUATED VARICELLA VACCINE
WATSON, B
GUPTA, R
RANDALL, T
STARR, S
[J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (01) : 197 - 199
[9] CELL-MEDIATED IMMUNE-RESPONSES AFTER IMMUNIZATION OF HEALTHY SERONEGATIVE CHILDREN WITH VARICELLA VACCINE - KINETICS AND SPECIFICITY
WATSON, B
KELLER, PM
ELLIS, RW
STARR, SE
[J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (04) : 794 - 799
[10] WATSON BM, 1993, PEDIATRICS, V91, P17

← 1 2 →