GERANYLGERANIOL IS A POTENT INDUCER OF APOPTOSIS IN TUMOR-CELLS

被引：97

作者：

OHIZUMI, H

MASUDA, Y

NAKAJO, S

SAKAI, I

OHSAWA, S

NAKAYA, K

机构：

[1] SHOWA UNIV,SCH PHARMACEUT SCI,SHINAGAWA KU,TOKYO 142,JAPAN

[2] EISAI & CO LTD,PROD FORMULAT RES LAB,HONJO,SAITAMA 367,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1995年 / 117卷 / 01期

关键词：

APOPTOSIS; GERANYLGERANIOL; ISOPRENOID; TUMOR CELL;

D O I：

10.1093/oxfordjournals.jbchem.a124695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent, DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.

引用

页码：11 / 13

页数：3

共 14 条

[1] ACTIVATION OF PROGRAMMED CELL-DEATH (APOPTOSIS) BY CISPLATIN, OTHER ANTICANCER DRUGS, TOXINS AND HYPERTHERMIA [J].