ASYMMETRIC KETONE REDUCTION USING CHIRAL OXAZABOROLIDINES DERIVED FROM AZIRIDINE CARBINOLS

被引：36

作者：

WILLEMS, JGH ^{[1
]}

DOMMERHOLT, FJ ^{[1
]}

HAMMINK, JB ^{[1
]}

VAARHORST, AM ^{[1
]}

THIJS, L ^{[1
]}

ZWANENBURG, B ^{[1
]}

机构：

[1] UNIV NIJMEGEN, CTR MOLEC STRUCT DESIGN & SYNTHESIS, DEPT ORGAN CHEM, NSR LAB, 6525 ED NIJMEGEN, NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 04期

关键词：

D O I：

10.1016/0040-4039(94)02313-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric borane reduction of acetophenone using 1,3,2-oxazaborolidines derived from aziridine-2-tertiairy alcohols 1 and 2 yielded the corresponding alcohol in high optical yields. The synthesis of the novel chiral catalysts 1 and 2 using D- and L-serine, and D- and L-threonine as starting material is described.

引用

页码：603 / 606

页数：4

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